Author(s):
Junaid Khan, Swarnlata Saraf, Shailendra Saraf
Email(s):
kallolkghosh@yahoo.com
Address:
Department of Pharmacy, Sarguja University, Ambikapur -497 001, India
University Institute of Pharmacy, P. Ravishankar Shukla University, Raipur 492 010, India.
Published In:
Volume - 29,
Issue - 1,
Year - 2016
Cite this article:
Khan, Saraf and Saraf (2016). Hepatoprotective Potential and Possible Mechanism of Schleichera oleosa. Journal of Ravishankar University (Part-B: Science), 29(1), pp.181-182.
PP-F11
Hepatoprotective
Potential and Possible Mechanism of Schleichera oleosa
Junaid Khan, Swarnlata Saraf and
Shailendra Saraf
Department of Pharmacy, Sarguja
University, Ambikapur -497 001, India,
University Institute of Pharmacy,
P. Ravishankar Shukla University, Raipur 492 010, India
Corresponding author email:
kallolkghosh@yahoo com
[Received
15 January 2016, accepted 29 January 2016]
Abstract: Schleichera
oleosa (Sapindaceae) commonly known as 'Koshamra' in Ayurveda is a tropical
tree readily found in Asia and is used to treat pain and rheumatism, as
traditional medicine in different parts of India. However, scientific evidences
to justify these claims are lacking. Considering the traditional use of
S.oleosa and the lack of information about its pharmacological properties, we
investigated the hepaprotective potential of the alcoholic extract of S.oleosa
(SME) against different animal models in rodents. The hepatoprotective activity
was evaluated against PCM and GalN/LPS induced hepatic damage. Furthermore, the
biochemical mediators like NO (Nitric oxide) and TNF-a were also estimated. The
ethanolic extract of S. oleosa bark, did not exhibit any signs of toxicity up
to a dose of 2000 mg/kg. The extract significantly reduced the serum level of
marker enzymes (p<0.05) indicating its hepatoprotective potential. The
histological changes induced by PCM and GalN/LPS were significantly ameliorated
by S.oleosa. The response of higher dose of extract was comparable with
standard drug silymarin. Histopathological examination of the liver tissues
stained with H&E revealed that control groups showed normal histological
appearance with structural integrity of hepatic cells without necrosis or
inflammation. The results suggest that Soleosa is effective against hepatic
damage and its action is markedly influenced by the inhibition of TNF-a and anti-oxidant
action.
Keywords: Tropical
tree, Hepatoprotective, TNF-a, Necrosis