Author(s):
Loxmi Jamoh, Angkita Sharma, Pallabi Kalita, Hui Tag
Email(s):
huitag2008rgu@gmail.com
Address:
Plant Systematic and Pharmacognosy Research Laboratory, Department of Botany, Rajiv Gandhi University, Rono Hills, Doimukh, Itanagar - 791 112, India
Department of Biotechnology & Chemical Engineering. National Institute of Technology, Itanagar 791 112, India.
Published In:
Volume - 29,
Issue - 1,
Year - 2016
Cite this article:
Jamoh, Sharma, Kalita and Tag (2016). Pharmacological Activity of Leaf Extract of Gonostegia hirta (BlumeEx Hasskarl) Miquel: A Wild Food Used by the Local People of Arunachal Pradesh, India. Journal of Ravishankar University (Part-B: Science), 29(1), pp.176-177.
PP-F03
Pharmacological
Activity of Leaf Extract of Gonostegia hirta (BlumeEx Hasskarl) Miquel: A Wild
Food Used by the Local People of Arunachal Pradesh, India
Loxmi Jamoh, Angkita Sharma,
Pallabi Kalita and Hui Tag
Plant Systematic and
Pharmacognosy Research Laboratory, Department of Botany, Rajiv Gandhi
University, Rono Hills, Doimukh, Itanagar - 791 112, India
Department of
Biotechnology & Chemical Engineering. National Institute of Technology,
Itanagar 791 112, India
Corresponding author email:
huitag2008rgu@ gmail.com
[Received
30 December 2015, accepted 28 January 2016]
Abstract: Gonostegia
hirta (Blume ex Hasskarl) Miquel (Urticaceae family), is a popular wild edible
food plant used by the local tribes of Arunachal Himalayan Region of India
which is ideally found in weedy places, thickets by ditches and rice field and
moist as well as semi-dry secondary forest patches. It is an herbs or
sub-shrubs (shrub), perennial used in the treatment of inflammation, ingestion
and constipation. The main aim of the study was to examine the pharmacological
potential with special reference to the psychopharmacological, toxicity and
antipyreticactivities.Gonostegia hirta (Blume ex Hasskarl) Miquel, were
collected from Siang District ofArunachal Pradesh (27°43' to 29°20' N latitude
and 44°42' to 95 35" E longitude) and crude methanolic extract the plant
was tested for their pharmacological activities in in-vivo rat models. The
toxicity study showed no mortality up to dose of 2000 mg/kg Anti-pyretic study
revealed that the methanolic extract exhibits significant antipyretic activity
with thereduction of yeast induced pyrexia temperature from 38.810.5 "C to
36.720.7 "C, with a dose level of 300mg/Kg which was comparable with
standard drug paracetamol.Theleafextract of the same plant tested for
psychopharmacological activity inphenobarbitone induced maximum sleeping time
of 19.812.5 minutes with a dose level of 300mg/Kg have shown no significant
psychopharmacological activity when compared with the standard
drugchlorpromazine. The results were analyzed and compared statistically using
Origin 8 software. The pharmacological efficacies of the leaf extract of
Gonostegia hirta (Blume ex Hasskarl) Miquelfrom Arunachal Pradesh shown in the
present study revealed no such harmful toxic effect on animal physiology and
also no such significant psychopharmacological effect was seen. Therefore,
present studies have concluded that traditional wild vegetables species used by
the local tribes are safe which validatesits popular use as antipyretic agents
as well as food sources by the local communities Arunachal Pradesh.
Keywords:
Gonostegiahirta, Arunachal Himalayan Region, Toxicity, Psychopharmacology,
Antipyretic