Cite this article:
Mittal, Joshi and Shukla (2016). Ameliorative Activity of Medicinal Plant and its Active Principle against Hepatorenal Toxicity. Journal of Ravishankar University (Part-B: Science), 29(1), pp.175-176.
PP-F01
Ameliorative
Activity of Medicinal Plant and its Active Principle against Hepatorenal
Toxicity
Deepak Kumar Mittal, Deepmala
Joshi and Sangeeta Shukla
Sri Satya Sai University of
Technology and Medical Sciences, Sehore, India
Corresponding author email:
deepakmittal05@gmail.com
[Received:
4 January 2016; accepted: 14 January 2016]
Abstract: Polygonum
bistorta plant locally known as a bistort, used in the Siddha system of
medicine. The goal of the present work is to evaluate and compare the efficacy
of root extract of Polygonum bistorta and tannic acid against CCL- induced
damage in liver and kidney. The hepatotoxicity produced by the administration
of CCL, at the dose of (1.5 and 0.15 ml kg' b.wt.) for once only (Acute
exposure) and 21 days (Sub chronic exposure), was found to be inhibited by
simultancous oral administration of aqueous extract of P. bistorta (100 mg
kg" b.wt.) and its active principle as tannic acid (25 mg kg" b.wt.)
after 24 h of CCL, administration. The enzymatic activities of AST, ALT and
SALP in serum where as LPO and GSH contents in liver and kidney were estimated
and histopathology of liver and kidney was performed after acute and sub
chronic exposure of CCL, and treatment and compared to the control. Severe
alterations were noticed after CCl, administration with evidence of increased
level of serum AST, ALT and SALP. The significant changes were noticed in LPO
and GSH contents with the concurrent administration of plant extract and its
active principle after CCI, administration. The histopathological changes were
reversed after the treatment of plant extract and its active principle. This
plant possesses a broad spectrum of antibiotic, antibacterial and anticancer
activity. The observations of this study indicated that aqueous extract of P.
bistorta roots and tannic acid could afford a better protection against CCL-
induced sub chronic hepatotoxicity in rats.
Keywords: Polygonum
bistorta, Tannic acid, Carbon tetrachloride, Lipid peroxidation, Reduced
glutathione