Cite this article:
Jeswani and Ajazuddin (2016). Bioactive Natural Compounds as Antihemolytic Agents: A Review. Journal of Ravishankar University (Part-B: Science), 29(1), pp.165-166.
PP-E07
Bioactive
Natural Compounds as Antihemolytic Agents: A Review
Gunjan Jeswani and Ajazuddin
Faculty of Pharmaceutical
Science, SSTC, Bhilai - 490 024, India
Novel Drug Development
Laboratory, Department of Pharmaceutics, Bhilai 490 024, India
Corresponding author email: gunjanjeswani@gmail.com
[Received
15 January 2016; accepted 29 January 2016]
Abstract: Herbs have
been extensively used since renaissance for benefit of mankind. Those used in
medicine, are recognized to have bioactive compounds having medicinal
properties like antioxidant, anti-inflammatory, antimicrobial, hypolipidemic,
antimutagenic, anticarcinogenic, etc. The radical scavenging or antioxidant
benefits of botanical bioactive compounds provide opportunities to utilize
their potential for prevention of drug related haemolytic toxicities,
preferably because the toxicity is caused due to oxidative stress. Antioxidants
derived from plants, such as flavonoids and related phenolic compounds are
beneficial compounds that protect cells against oxidative destruction. Red
blood cell membrane contains high amount of polyunsaturated fatty acids that are
vulnerable to oxidative damage, which leads to cell lysis and predispose to
haemolytic anaemia Therefore, antioxidants that scavenge reactive oxygen
species or chelate metal transition ions have pronounced value in preventing
the drug induced haemolytic anaemia. Species like Eriobotrya japonica,
Clinacanthusnutans, Silybummarianum, Maytenusroyleanus, Psidium guajava are
some of the explicit examples Researchers are continuously discerning
strategies to explore their antioxidant capabilities in order to reduce drug
induced hemolysis. Among the various medicinal plants, some with potential
antihemolytic effects have been validated but many such plants remain to be
explored and can be investigated in the near future. The objective of this
study is to furmish a comprehensive review on plants bearing antihemolytic
activity and their scope in reducing drug induced hemolysis.
Keywords:
Antihemolytic agent, Haemolysis, Bioactive, Antioxidant, Reactive oxygen
species