Cite this article:
Gayatree (2016). Development of Phytovesicles of Plant Constituents via Complexation with Phospholipid. Journal of Ravishankar University (Part-B: Science), 29(1), pp.156-157.
PP-D07
Development of
Phytovesicles of Plant Constituents via Complexation with Phospholipid
Gayatree
University Institute of Pharmacy,
Pr. RavishankarShukla University, Raipur - 492 010, India
Corresponding author email:
Gayatri.deshlahre@gmail.com
[Received
20 January 2016; accepted 1 February 2016]
Abstract: Development
of phytovesicle is a new approach for plant extracts and active components. It
is a type of novel drug delivery systems (NDDS). The other available approaches
for novel herbal formulations like polymeric nanoparticles, nanocapsules,
liposomes, phytosomes, nanoemulsions, microsphere, niosomes, planterosomes,
cubosomes, transferosomes, and ethosomes has been reported using bioactive and
plant extracts. Many plant extracts and phytoconstituents, despite having
excellent bioactivity in vitro, but have less or no in vivo actions due to
their poor lipid or water solubility or improper molecular size or destruction
in gut. Drug delivery system for polyphenolic phytoconstituents (phytosomes)
was prepared by complexing polyphenolic phytoconstituents with phospholipid
mainly phosphatidylcholine which bind components to each other on a molecular
level. Bioavailability is enhanced due to their capacity to cross the lipid
rich bio-membranes and to protect the valuable components of the herbal extract
from destruction by digestive secretions and gut bacteria. Phytovesicle have
the capacity to deliver the standardized plant extracts and phytoconstituents
through several routes of drug administration. Phytovesicles absorption in GIT
is greater resulting in increased plasma level than individual component.
Phytovesicles act as bridge between novel delivery system and conventional
delivery system. Phospholipids molecule acting as vital carrier made up of
water soluble head and two fat soluble tails, due to this nature they possess
dual solubility and thus acting as an effective emulsifier. Phytosome
represents a promising vesicular drug delivery system to deliver therapeutic
compounds for a wide range of possible applications.
Keywords:
Phytovesicle, Phytosome, Polyphenolic