Cite this article:
Singh and Suresh (2016). Nanostructured Lipid Carrier Enriched Cream for Topical Delivery of Betamethasone Valerate. Journal of Ravishankar University (Part-B: Science), 29(1), pp.151.
PP-C13
Nanostructured
Lipid Carrier Enriched Cream for Topical Delivery of Betamethasone Valerate
Prameet Singh and Preeti K Suresh
University Institute of Pharmacy,
Faculty of Technology, Pt. Ravishankar Shukla University, Raipur - 492 010,
India
Corresponding author email: suresh.preeti@
email.com
[Received
20 January 2016; accepted I February 2016]
Abstract: The aim of
present study was to develop, characterize and optimize nanostructured lipid
carriers (NLC) for topical delivery of betamethasone valerate, to assess in vitro
drug release and ex vivo permeation profile. The role of the developed cream
was compared with the conventional dosage form for topical delivery of the
active. Betamethasone valerate loaded NLCS were prepared by solvent diffusion
technique. The NLCS were lyophilized and their crystallinity was characterized
by differential scanning calorimetry (DSC). The optimized NLCS had an average
particle size of 390.8 nm, zeta potential of 26.7 mV and entrapment efficiency
of 86.84%. The NLCS were incorporated in 0.1% w/w stearic acid cream base and
in vitro skin deposition was studied in goat ear skin. Significantly higher
deposition of betamethasone valerate was found in goat ear skin from NLC cream
as compared to betamethasone valerate plain cream. The developed cream appears
to be a potential strategy for treatment of topical skin diseases.
Keywords:
Betamethasone valerate, Nanostructured lipid carrier, Permeation, Skin, Topical
delivery