PP-C08

Development and Characterization of Hydroxyapatite Based Nanocomposites for Local Drug Delivery to Periodontal Pockets

Indu Lata Kanwar

University Institute of Pharmacy, P Ravishankar Shukla University, Raipur - 492 010, India

Corresponding author email: indukanwar9@gmail.com

(Received 20 January 2016,; accepted 1 February 2016)

Abstract: The aim of this study is to fabricate hydroxyapatite based nanocomposites for local drug delivery in periodontal pockets. Hydroxyapatite is chemically similar to the mineral component of bones and hard tissues in mammals. Synthetic biocompatibility and bioactivity with human teeth and bone making it very attractive for biomedical applications. Nanocomposites is a multiphase solid material where one of the phases has one, two or three dimensions of less than 100 nanometres (nm), or structures having nano-scale repeat distances between the different phases that make up the material. Nanostructured calcium phosphate materials play an important role in the formation of hard tissues in nature. It is reported that calcium phosphates materials in nano-size can mimic the dimensions of constituent components of calcified tissues. Nano-sized materials offer improved performances compared with conventional materials due to their large surface-to- volume ratios. The specific biological properties of the nanocomposites, as well as their interaction with cells, including the use of bioactive molecules. The approach of periodontal tissue engineering is considered promising to restore bone defect through the use of engineered materials with the aim that they will prohibit the invasion of fibrous connective tissue and help repair the function during bone regeneration.

Keywords: Hydroxyapatite, Nanocompoite, Bioactive molecule