PP-C04

Designing of Guggulsterone Beads f or the Treatment of Rheumatoid Arthritis

Shikha Srivastava, Manju R Singh and Deependra Singh

University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur - 492 010, India

Corresponding author email: Shikha_ceutics@yahoo.co.in

(Received 16 January 2016; accepted 30 January 2016)

Abstract: Guggulsterone had been shown to be ef guggulsterone is a concern for such treatment. This work aims at the development of oral drug delivery system by controlled release of guggulsterone, loaded in beads for the management of rheumatoid arthritis. The beads of guggulsterone prepared using the solvent evaporation method. The physio-chemical characterisation of beads was carried out to obtain information about particle size distribution, drug loading efficiency, morphology, thermal properties, polymorphism and release trends in phosphate-buffered saline at pH 7.4 and 378°C. The beads were found to be biocompatible as evidenced fromin vitro and in vivo studies using a rabbit synovial cells and Wistar rats, respectively. Guggulsterone release from beads of selected formulations showed biphasic nature due to initial burst effect followed by a controlled release. These results suggest that optimised - guggulsterone loaded beads may be the viable strategy for controlled release of guggulsterone in the joint for more than 30 days by oral administration to treat rheumatoid arthritis. ive in the management of arthritis. However, bioavailability of

Keywords: Guggulsterone, Controlled release, Beads, Rheumatoid arthritis, Drug delivery