Cite this article:
Verma and Saraf (2016). Designing of Quercetin Loaded Mannosylated Nanoparticles for Treatment of Skin Cancer. Journal of Ravishankar University (Part-B: Science), 29(1), pp.143-144.
Quercetin Loaded Mannosylated Nanoparticles for Treatment of Skin Cancer
Nikita Verma and Swarnlata Saraf
University Institute of Pharmacy,
Pt. Ravishankar Shukla University, Raipur - 492 010, India
Corresponding author email: firstname.lastname@example.org
4 January 2016; accepted: 14 January 2016]
Abstract: In the
present study the nanoprecipitation (or solvent displacement) method was
employed to prepare the Chitosan -QUNLS with improved drug incorporation and loading
properties. The response surface method with quadratic model was employed to
study the effect of selected parameters in the formulation of nanoparticles.
The response variable of optimized formulation was fond to be percentage drug
entrapment efficiency 51%, 2.89% drug loading capacity and 31.4% drug release.
The drug entrapment efficiency of the nanoparticles increases with polymer
ratio. Delivery system F, (with Drug:Polymer ratio 1:45), sonication time 15
min. showed maximum drug entrapment efficiency (51%) and Drug loading capacity
2.89% and maximum drug release 31.4% and the mannosylated form of these
formulation sahowed 39.1%entrapment efficiency, 1.79% drug loading capacity.
These optimized nanocarrier also showed diffusion controlled prolonged release
of medicament as indicated shown by in-vitro drug relcase studies. The average
size of the optimized formulation were around 112 nm and the average diameter
of mannosylated form were 125.7 and zetapotential value -24.4 and -23.7
respectively. The resultant nanoparticles were nearly rough rather than smooth
as seen under TEM. All the result provides supplementary evidences that the
QUNLS have good entrapment efficiency and drug loading capacity than the
mannosylated nanoparticles (M-QUNLS). And on the basis of results we can
concluded that the QUNLS and M-QUNLS have good entrapment efficiency, drug
loading capacity, mean particle size diameter and zeta potential by the
stability point of view and have great targeting and prolonged release effect
with great potential in topical delivery.
Keywords: Skin Cancer,
Mannovylated nanoparticles, Solvent Displacment method, Chitosan, Quercetin