GL-F05

Fabrication of Nanocargoes with Endogeneous Ligands for Enhancing Cell Targetability

Swarnlata Saraf

University Institute of Pharmacy, Pr. Ravishankar Shukla University, Raipur, Chhattisgarh, India

Corresponding author email: swurnlata_sarofe gmail.com

[Received 12 January 2016]

Abstract: The application of nanotechnology in advancing drug delivery and imaging system in vivo is a vigorously increasing. Development of nanocarriers with an approach of surface modification, surface engineering, complexation or biotechnically armed products has opened new pathways in active targeting. These Intelligent nanocarriers have remarkable cell specificity and targetability irrespective of the drug encapsulated or loaded. The aim of our study was to design such nanocargoes which on attaching with endogeneous ligands acts as an effective carrier for targeting as well as also shows desired cellular uptake and response. Our results showed that the fabricated nanoccargoes have significant stability, functional flexibility, low toxicity, and ability to control the release of drugs. Our research led to the conclusion that more research into these nanoacargoes will elaborate the understanding of the interactions of these carrier materials with biological systems, endogeneous ligands for more effective futuristic delivery system

Keywords: Nanocarriers, Active Targeting. Endogeneous Ligands Functional Flexihility, Low Toxicity