Author(s):
PV Khawse, VA Dhande, VD Rangari, SG Gurunani, VD Gulkari, DR Chaple
Email(s):
khawsepriti@yahoo.co in
Address:
Priyadarshini JL College of Pharmacy, Electronics Zone, MIDC, Hingna Road, Nagpur - 440 016, India.
Published In:
Volume - 29,
Issue - 1,
Year - 2016
Cite this article:
Khawse, Dhande, Rangari, Gurunani, Gulkari and Chaple (2016). Reconnoitering Capparis zeylanica Seeds as Hepatoprotective Agent. Journal of Ravishankar University (Part-B: Science), 29(1), pp.133-134.
PP-B06
Reconnoitering
Capparis zeylanica Seeds as Hepatoprotective Agent
PV Khawse, VA Dhande, VD Rangari,
SG Gurunani, VD Gulkari and DR Chaple
Priyadarshini JL College of
Pharmacy, Electronics Zone, MIDC, Hingna Road, Nagpur - 440 016, India
Corresponding author email:
khawsepriti@ yahoo.co in
(Received
15 January 2016; accepted 2 February 2016)
Abstract: Many
hepatoprotective herbal preparations have been recommended in alternative
systems of medicine for the treatment of hepatic disorders. No Systematic study
has been done on protective efficacy of seeds of capparis zeylanica
(Capparidaceae) to treat hepatic diseases. Protective action of Capparis
zeylanica seeds methanolic and butanolic extract was evaluated in this study in
an animal model of hepatotoxicity, which was induced by carbon tetrachloride.
Heathy albino rats (100-150g body weight) were divided into 7 groups. Group 1
was normal control group; group 2, the hapatotoxic group was given CCL: group 3
was administered with standard (Silymarin); group 4-5 received different doses
of methanolic extract (200,400 mg/kg) with CCL: Group6-7 was administered dose
of the butanolic extract(200-400mg/kg) . The parameters studied were SGPT
(Serum glutamic pyruvic transaminase), SGOT (Glutamic-oxalacetic transaminase),
and ALP (Alanine Aminotransferase). The hepatoprotective activity was also
supported by histopathological study of liver tissue. Results of the
biochemical studies of blood samples of CCL, treated animal sbowed significant
increase in the levels of serum enzyme activities, reflecting the liver injury
caused by CCL whereas blood samples from the animals treated with butanolic
extract showed significant decrease in the levels of serum markers as compared
to the methanolic extract, indicating the protection of hepatic cells. The
results revealed that butanolic extract of C. zeylanica could afford significant
dose-dependent protection against CCI, induced hepatocellular injury.
Keywords: Capparis
zrylanica, Hepatoprotective activity. Antioxidant activity