Cite this article:
Sahu and Pradhan (2016). Acetylcholinesterase Inhibition Property in Wild Edible Fruits of Chhattisgarh. Journal of Ravishankar University (Part-B: Science), 29(1), pp.123-124.
PP-A19
Acetylcholinesterase
Inhibition Property in Wild Edible Fruits of Chhattisgarh
Gyanchandra Sahu and RK Pradhan
School of Life Sciences, Pt.
Ravishankar Shukla University, Raipur - 492 010, India
Corresponding author email:
rkp299@ gmail.com
[Received
21 January 2016, accepted 27 January 2016]
Abstract: Alzheimer's
disease (AD) is a progressive, neurodegenerative disorder that mainly affects
the elderly population and is considered to be responsible for majority of the
dementia among old peoples. Because of its debilitating nature, it becomes a
burden on the society. Keeping in view the increasing old population, the
significance of AD is further compounded as the number of identified cases is
estimated to be many folds in coming few decades. On the other hand, currently
there is no cure for this disorder and much of the treatments available can
only delay the progression of the disease Therefore there is an urgent need for
a different approach to the treatment of AD. Plants have been a source of
medicine for the treatment of several disease including cognitive disorders,
like AD since innumerable tirhes. Therefore ethnopharmacological screening of
plants may be a better option in the discovery of new drugs for AD therapy.
Treatment of Alzheimer's disease is based on inhibition of the enzyme
Acetylcholinesterase (ACHE). The present paper deals with screening of wild
edible fruits for inhibitory property to Acetylcholinesterase Enzyme. The study
was carried out on methanol and aqueous extracts of fresh ripe and unripe Ficus
bengalensis, Ziziphus oenoplia, Ficus racemosa, Bridelia retusa, Carissa
carandas and Annona squamosa fruits. ACHE activity was measured by colorimetric
method. Eserine was used as reference inhibitor for determining percent inhibition.
Results show that fresh unripe fruits have significantly higher inhibition than
ripe fruits except Carissa carandas. The highest ACHE inhibition (81.5 %) was
found in methanol extract of fresh unripe fruit Bridelia retusa and lowest
inhibition (4.48%) was observed in aqueous extract of fresh ripe fruit Annona
squamosa. Further it was also noticed that ripening process decrease inhibition
potency in edible fruits. From the findings of this study it can be concluded
that consumption of fresh unripe fruits may be more beneficial than ripen
fruits.
Keywords: Alzheimer's
disease, Acetylcholinesterase, Wild fruits, Inhibition