Cite this article:
Sahu and Jain (2016). Enhanced Oral Bioavailability of Plant Active Naringenin through Solid Lipid Nanoparticulate Carrierby Intestinal Lymphatic Delivery. Journal of Ravishankar University (Part-B: Science), 29(1), pp.114-115.
PP-A04
Enhanced Oral
Bioavailability of Plant Active Naringenin through Solid Lipid Nanoparticulate
Carrierby Intestinal Lymphatic Delivery
Anil Kumar Sahu and Vishal Jain
University Institute of Pharmacy,
Pr. Ravishankar Shukla University, Raipur - 492010, India
Corresponding author email:
anil2484@ gmail.com
[Received
4 January 2016, accepted 12 January 2016]
Abstract: The aim of
the present work was to design and develop Naringenin (NGN) loaded solid lipid
nanoparticles (NGN- SLN) to improve the oral bioavailability by intestinal
lymphatic delivery. Naringenin (4', 5, 7-trihydroxyflavanone) is a citrus
flavonoid mainly obtaincd from the citrus fruits. It degrades in low pH and
enzymatic condition of gastrointestinal tract having very low oral absolute
bioavailability about 8% along with 2-3h half-life. The NGN-SLN was composed of
riglycerides, lecithin and various aqueous surfactants, were optimized using
hot homogenization followed by ultrasonication method. The optimized SLN had
particle size of 110:5.48 nm, EE of 91.317 83% and zeta potential
33.52.11mV.The drug release of NGN SLN showed initial burst release followed by
the sustained release. TEM stady confirmed the almost spherical in shape. Solid
state characterization using differential scanning calorimeter (DSC) and powder
X-ray diffraction (PXRD) analysis confirmed the homogeneous distribution of NGN
within the lipid matrix. The 5.25 fold increase in AUC after intraduodenal
administration of NGN-SLN in rats treated with saline in comparison to rats
treated with cycloheximide (a blocker of intestinal lymphatic pathway),
confirmed its intestinal lymphatic delivery. On the above experimental results
indicate that SLN may offer a promising strategy for improving the oral bioavailability
of therapeutic agents.
Keywords: Naringenin, SLN, Intestinal lymphatic delivery. Oral bioavailability