GL-F01

Exploitation of Ethno-Medicinal Knowledge through Identification of Novel Molecules through Instrumental Techniques for Drug Design

A K Geda and P K Joshi

Centre of Excellence on MAP and NTFP. Indira Gandhi Krishi Vishwavidyalaya, Raiput 4920, India

Correpending author email: akgeda@ yahoo.co.in

[Received M December 2015)

Abstract: The Chhattisgarh state of India is one of the best representatives of the Deccan Peninsular bio-geographic zune. It has vast heritage of diverse ethnic groups enriched with hiodiversity represents the tIreasure house of ethno botanical wealth The state tribes are worked as traditional healers and accumulated a great deal of knowledge on ethno-medicine. The importance of these traditional medicines has been realized world wide as some of them proved to be very effective. It needs scientific validation through quality control for commercialization of formulations. This rescarch paper represents the approaches for the herbal formulations, standardization including chemical, biological, pharmacological and molecular studies for drug design. Keeping in view, the preliminary information's has to be recorded from traditional healers using medicinal plants akong with their habit, habitat, taxonomy, useful plant part, age etc. Initially, the scientific study should be carmied out with the preparation of extracts of single or representative sample of botanicals, fractionated for their pharmacological studies for particular disorder. The molecules of responded extract play an important role for identification of novel new/ phyto-chemical molecules which can be isolated by chromatographic techniques (Column. TLC). The identification and structure elucidation of new molecule may be done by instrumental techniques (UV, IR, 'H, "C_NMR & Mass Spectra). In case, the availability of known molecules, the botanical extract can casily be identified by TLC, HPLC, LC MS MS and GC & GC_MS for volatiles with the application of standard/marker compound. The characterized novel molecule may be tested as single drug. for remedies of particular diseasel disorder. A study of biosynthesis pathway of respective molecules will be helpful to support the establishment of new drug design as synthetic organic molecule leading to the drug discovery.

Keywords: Medicinal plants, herbal formulations, HPLC